Author

T. Roychowdhury

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Evolutionary Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

S. Chatterjee· 2 shared S. Panda· 2 shared A. Dutta· 1 shared Angela WoodiD· 1 shared D. K. Biswal· 1 shared Emanuele Di AngelantonioiD· 1 shared Jack William O’SullivaniD· 1 shared John DaneshiD· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiophysics

S. Chatterjee

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Author profile →

4 papers

Recent·Most cited

Evaluating the cost-effectiveness of polygenic risk score-stratified screening for abdominal aortic aneurysm

Martin Kelemen, John Danesh, Emanuele Di Angelantonio, Michael Inouye, Jack William O’Sullivan, Lisa A M Pennells, T. Roychowdhury, Michael J. Sweeting, Angela Wood, Seamus C. Harrison, Lois G. Kim

This study evaluates the cost-effectiveness of polygenic risk score-stratified screening for abdominal aortic aneurysm compared to current strategies.

Nature Communications · Sep 14, 2024Peer-reviewedGenetic & Genomic Medicine

In Silico designed cell-penetrating anti-cancer peptide specifically inhibits VEGF-A expression

N. Banerjee, L. Roy, S. Panda, T. Roychowdhury, S. Chatterjee

The paper designs in silico peptides that stabilize VEGF-A G-quadruplexes, reducing gene expression and inhibiting angiogenesis in cancer cells.

bioRxiv · Feb 8, 2024 · PreprintBiophysics

ALTering cancer by triggering telomere replication stress through the stabilization of promoter G-quadruplex in SMARCAL1

S. Panda, T. Roychowdhury, A. Dutta, S. Chakraborty, T. Das, S. Chatterjee

This study shows that stabilizing G-quadruplex in SMARCAL1 promoter reduces its expression, increases replication stress, and promotes DNA damage in ALT-positive cancer cells, suggesting G4 stabilizers as potential therapeutics.

bioRxiv · Feb 1, 2024 · PreprintBiochemistry

De novo genome and transcriptome analyses provide insights into the biology of the trematode human parasite Fasciolopsis buski

D. K. Biswal, T. Roychowdhury, P. Pandey, V. Tandon

The paper performs transcriptome and genome analyses of Fasciolopsis buski to characterize its biology and identify resources for diagnostic and therapeutic development.

bioRxiv · Jun 23, 2018Evolutionary Biology