Author

Seamus C. Harrison

Genomics (United Kingdom)ORCID 0009-0008-0973-3557Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:GWAS summary statistics· 2 Organism:human· 2 Research Focus:benchmarking· 1 Organism:mouse· 1 Research Focus:polygenic risk· 1

Frequent Co-Authors

Jack William O’SullivaniD· 2 shared John DaneshiD· 2 shared Michael J. SweetingiD· 2 shared Adam S. ButterworthiD· 1 shared Alison J. FiniganiD· 1 shared Angela WoodiD· 1 shared Benjamin B. SuniD· 1 shared Céline GrenieriD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Jack William O’SullivanORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Genetic & Genomic MedicineNature CommunicationsPeer-reviewedJan 21, 2026

Preventing premature deaths through polygenic risk scores

Melisa Chuong, Deborah J. Thompson, Michael E. Weale…·Jack William O’Sullivan

This study evaluates how polygenic risk scores can optimize screening programs to reduce premature deaths by tailoring screening ages based on genetic risk.

4 citationstop 2%

humanGWAS summary statistics

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Genetic & Genomic MedicineNature CommunicationsPeer-reviewedSep 14, 2024

Evaluating the cost-effectiveness of polygenic risk score-stratified screening for abdominal aortic aneurysm

Martin Kelemen, John Danesh, Emanuele Di Angelantonio…·Lois G. Kim

This study evaluates the cost-effectiveness of polygenic risk score-stratified screening for abdominal aortic aneurysm compared to current strategies.

17 citationstop 4%

humanGWAS summary statistics

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GeneticsCirculation Genomic and Precision MedicinePeer-reviewedFeb 1, 2019

Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates

Ellie Paige, Marc Clément, Fabien Lareyre…·Ziad Mallat

The paper investigates the effect of the IL6R-Asp358Ala variant on AAA growth and evaluates IL-6 pathway blockade in mouse models, finding no significant growth rate reduction but improved survival with trans-signalling inhibition.

64 citationstop 2%

mousestatistical model

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