P. Pandey

In bacterial membranes lipid II changes the stability of pores formed by the antimicrobial peptide nisin

This study shows that lipid II in bacterial membranes stabilizes pores formed by nisin, enhancing its antimicrobial effect by altering membrane properties.

Molecular Regulation of Invasive Protrusion Formation at the Mammalian Fusogenic Synapse

The paper identifies the spatiotemporal coordination of WAVE and N-WASP with actin-bundling proteins in invasive protrusion formation at the mammalian fusogenic synapse.

Cardiomyocyte mechanical memory is regulated through the talin interactome and DLC1 dependent regulation of RhoA

The paper identifies DLC1's role in regulating RhoA activity through the talin interactome, linking mechanical memory to cardiac phenotype changes.

A RabGAP-Rab GTPase pair regulates plant autophagy and immunity

This study identifies Rab3GAPL as a regulator of plant autophagy and immunity by modulating Rab8a and ATG8 interactions.

sAMP-VGG16: Drude polarizable force-field assisted image-based deep neural network prediction model for short antimicrobial peptides

This paper introduces an image-based deep neural network model for predicting antimicrobial peptides using Drude polarizable force-field atom types, achieving high accuracy and efficiency.

A familial natural short sleep mutation promotes healthy aging and extends lifespan in Drosophila

This study shows that the dec2P384R mutation in Drosophila extends lifespan and improves health by enhancing mitochondrial function and stress response pathways despite reduced sleep.

Eggplant's chlorogenic acid provides resistance against the tropical armyworm

This study identifies chlorogenic acid (CGA) in eggplant as a larvicidal compound effective against the tropical armyworm, with potential as a safe biopesticide.

Stress Combinations and their Interactions inPlants Database (SCIPDb): A one-stop resource for understanding combined stress responses in plants

SCIPDb is a database that compiles phenome and transcriptome data on plant responses to combined stresses, identifying novel genes and pathways involved in stress tolerance.

Discovery, Synthesis, and Optimization of 1,2,4-Triazolyl Pyridines Targeting Mycobacterium tuberculosis

This paper discovers and optimizes a new series of 1,2,4-triazolyl pyridines that inhibit Mycobacterium tuberculosis growth with nanomolar activity and favorable pharmacokinetics.

Anticancer drug doxorubicin spontaneously reacts with GTP and dGTP

This study shows doxorubicin forms covalent conjugates with GTP and dGTP, which are less cytotoxic and cannot enter nuclei, suggesting doxorubicin may target nucleotides involved in cellular energy processes.

Regulation of Cardiomyocyte Adhesion and Mechanosignalling Through Distinct Nanoscale Behaviour of Integrin Ligands Mimicking Healthy or Fibrotic ECM

This study investigates how integrin-ligand combinations affect cardiomyocyte adhesion, traction forces, and mechanosignalling in healthy and fibrotic ECM environments.

Prediction of range expansion and estimation of dispersal routes of water deer (Hydropotes inermis) in the transboundary region between China, the Russian Far East and the Korean Peninsula

This study predicts water deer range expansion and dispersal routes in Northeast Asia using MaxEnt and circuitscape, identifying key habitats and potential conservation corridors.

Simultaneous therapeutic targeting of inflammation and virus ameliorates influenza pneumonia and protects from morbidity and mortality

This paper shows that combining antiviral and anti-inflammatory drugs reduces IAV pneumonia severity and mortality in mice by lowering viral load and inflammation.

An investigation into the spatiotemporal patterns of the Nymphalid butterfly Vagrans egista sinha (Kollar, )

This study investigates the range extension of the Himalayan Vagrant butterfly, finding no range shift or vagrancy, and highlights issues with citizen science data accuracy.

Wheat inositol pyrophosphate kinase TaVIH2-3B modulates cell-wall composition for drought tolerance in Arabidopsis

This study identifies TaVIH2-3B, a wheat PPIP5K homolog, which enhances drought tolerance in Arabidopsis by modulating cell-wall composition through increased polysaccharide accumulation.

B.1.617.3 SARS CoV-2 spike E156G/Δ157-158 mutations contribute to reduced neutralization sensitivity and increased infectivity

This study identifies spike mutations in B.1.617.3 SARS-CoV-2 variants that reduce neutralization sensitivity and increase infectivity.

CaProDH2-mediated modulation of proline metabolism confers tolerance to Ascochyta in chickpea under drought

This study identifies CaProDH2 as a key gene in the proline-P5C cycle that enhances chickpea resistance to Ascochyta rabiei under drought conditions.

Chloroplasts alter their morphology and accumulate at the pathogen interface during infection by Phytophthora infestans

This study shows chloroplasts accumulate at the pathogen interface during Phytophthora infestans infection, forming stromules, and this process is partially actin-dependent but not light-dependent.

A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component

This study shows that the bacterial effector XopL suppresses plant autophagy by degrading SH3P2, revealing a novel pathogen strategy to evade host defense.

Altering the solubility of the antibiotic candidate Nisin - a computational study

This study uses molecular dynamics simulations to investigate how mutations affect nisin solubility and evaluates force fields' ability to model solubility of uncommon amino acids.

A comparative study of stress responses elicited by misfolded proteins targeted by bipartite or matrix-targeting signal sequences to yeast mitochondria

This study compares stress responses in yeast mitochondria caused by misfolded proteins targeted to the IMS or matrix using different signal sequences, revealing compartment-specific adaptations.

Does visitation dictate animal welfare in captivity? A case study of tigers and leopards from National Zoological Park, New Delhi

This study examines the impact of visitor density on stereotypic behaviors in tigers and leopards at a zoo, finding significant associations with visitor numbers but not ambient noise.

Gone in 40 years, the curious case of the Himalayan Quail: an attempt at rediscovery and implications for conservation

This study investigates the potential rediscovery of the Himalayan Quail and identifies factors contributing to its decline, concluding that past efforts have been ineffective and suggesting new methods for future searches.

The Irish potato famine pathogen subverts host vesicle trafficking to channel starvation-induced autophagy to the pathogen interface

This study shows how the potato blight pathogen P. infestans uses the effector PexRD54 to redirect host autophagy towards the pathogen interface, benefiting the pathogen.

Poxvirus-encoded TNF receptor homolog dampens inflammation and protects the host from uncontrolled lung pathology and death during respiratory infection

This study shows that the ECTV CrmD protein reduces inflammation and protects mice from lethal lung disease during respiratory infection by modulating TNF, IL-6, IL-10, and IFN-γ.

TNF deficiency dysregulates inflammatory cytokine production leading to lung pathology and death during respiratory poxvirus infection

This study shows TNF deficiency during ECTV infection leads to excessive cytokine production and lung damage, which can be mitigated by STAT3 inhibition.

The mechanisms of dynamin-actin interaction

This study identifies a noncanonical role for dynamin in cell-cell fusion by directly bundling actin filaments through GTPase-dependent interactions.

Alternative stable states in a model of microbial community limited by multiple essential nutrients

The paper introduces a model of microbial communities with multiple stable states and demonstrates how nutrient limitations and competitive abilities lead to alternative stable states and regime shifts.

De novo genome and transcriptome analyses provide insights into the biology of the trematode human parasite Fasciolopsis buski

The paper performs transcriptome and genome analyses of Fasciolopsis buski to characterize its biology and identify resources for diagnostic and therapeutic development.

Conventional and hyperspectral time-series imaging of maize lines widely used in field trials

The paper phenotypes maize lines using conventional and hyperspectral imaging, showing correlations between image data and manual measurements, and highlights unique hyperspectral signatures in stem tissue.