Author

T. Sadaoka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Assay:long-read sequencing· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

D. P. Depledge· 3 shared A. Venkatesan· 2 shared J. Breuer· 2 shared L. Rajbhandari· 2 shared W. J. D. Ouwendijk· 2 shared A. Wilson· 1 shared B. Jagdish· 1 shared D. Beady· 1 shared

Activity by Year

2018-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMicrobiology

D. P. Depledge

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Author profile →

4 papers

Recent·Most cited

Expression of varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency

W. J. D. Ouwendijk, D. P. Depledge, L. Rajbhandari, T. R. Rovis, S. Jonjic, J. Breuer, A. Venkatesan, G. M. G. M. Verjans, T. Sadaoka

This study identifies VLT-ORF63 fusion transcripts in VZV-infected neurons, showing they drive lytic gene expression during reactivation from latency.

bioRxiv · Sep 11, 2020Microbiology

Decoding the architecture of the varicella-zoster virus transcriptome

S. E. Braspenning, T. Sadaoka, J. Breuer, G. Verjans, W. J. D. Ouwendijk, D. P. Depledge

This study reannotates the VZV transcriptome using RNA sequencing to identify 136 polyadenylated RNAs, including ORFs, non-canonical ORFs, ORF fusions, and ncRNAs, revealing unexpected kinetic classes of viral transcripts.

bioRxiv · May 25, 2020Microbiology

Human stem cell derived sensory neurons are positioned to support varicella zoster virus latency

T. Sadaoka, L. Rajbhandari, P. Shukla, B. Jagdish, H. Lee, G. Lee, A. Venkatesan

This study investigates VZV latency and reactivation in human sensory neurons, finding they resist lytic infection but support latency and reactivation, mirroring in vivo conditions.

bioRxiv · Jan 24, 2020 · PreprintMicrobiology

Native RNA sequencing on nanopore arrays redefines the transcriptional complexity of a viral pathogen

D. P. Depledge, S. Kalanghad Puthankalam, T. Sadaoka, D. Beady, Y. Mori, D. Placantonakis, I. Mohr, A. Wilson

This study uses nRNA-seq to analyze the herpes simplex virus type 1 transcriptome, identifying a novel intergenic mRNA encoding a fusion protein of ICP0 and L.

bioRxiv · Jul 20, 2018Microbiology