Author

D. P. Depledge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Evolutionary Biology· 1

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Organism:human· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Approach:deep learning· 3 Research Focus:differential expression· 3 Assay:long-read sequencing· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

J. Breuer· 3 shared T. Sadaoka· 3 shared A. C. Wilson· 2 shared A. Wilson· 2 shared G. M. G. M. Verjans· 2 shared I. Mohr· 2 shared W. J. D. Ouwendijk· 2 shared A. Babnis· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersMicrobiology

J. Breuer

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Author profile →

8 papers

Recent·Most cited

Histone H2A variant H2A.B is enriched in transcriptionally active HSV-1 lytic chromatin

E. Flores Cortes, S. Saddoris, A. K. Owens, R. Gibeault, D. P. Depledge, L. M. Schang

This study identifies H2A.B as a histone variant enriched in dynamically chromatinized HSV-1 lytic chromatin, suggesting its role in promoting transcriptional activity.

bioRxiv · Dec 22, 2023 · PreprintMicrobiology

Reanalysis of single-cell RNA sequencing data does not support herpes simplex virus 1 latency in non-neuronal ganglionic cells in mice

W. J. Ouwendijk, P. Roychoudhury, A. L. Cunningham, K. R. Jerome, D. M. Koelle, P. R. Kinchington, I. Mohr, A. C. Wilson, G. M. G. M. Verjans, D. P. Depledge

The paper reanalyzes scRNA-Seq data and finds that HSV-1 latency in non-neuronal ganglionic cells is not supported, attributing the previous findings to technical artifacts.

bioRxiv · Jul 17, 2023Microbiology

DLK-dependent biphasic reactivation of herpes simplex virus latency established in the absence of antivirals

S. A. Dochnal, H. Merchant, A. Schinlever, A. Babnis, D. P. Depledge, A. Wilson, A. R. Cliffe

This paper introduces a new HSV-1 reporter virus, Stayput-GFP, to study latency and reactivation in neurons without antivirals, revealing DLK-dependent Phase I reactivation and histone demethylase-dependent Phase II reactivation.

bioRxiv · Feb 25, 2022Microbiology

Expression of varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency

W. J. D. Ouwendijk, D. P. Depledge, L. Rajbhandari, T. R. Rovis, S. Jonjic, J. Breuer, A. Venkatesan, G. M. G. M. Verjans, T. Sadaoka

This study identifies VLT-ORF63 fusion transcripts in VZV-infected neurons, showing they drive lytic gene expression during reactivation from latency.

bioRxiv · Sep 11, 2020Microbiology

Decoding the architecture of the varicella-zoster virus transcriptome

S. E. Braspenning, T. Sadaoka, J. Breuer, G. Verjans, W. J. D. Ouwendijk, D. P. Depledge

This study reannotates the VZV transcriptome using RNA sequencing to identify 136 polyadenylated RNAs, including ORFs, non-canonical ORFs, ORF fusions, and ncRNAs, revealing unexpected kinetic classes of viral transcripts.

bioRxiv · May 25, 2020Microbiology

Novel splicing and open reading frames revealed by long-read direct RNA sequencing of adenovirus transcripts

A. M. Price, K. E. Hayer, D. P. Depledge, A. C. Wilson, M. D. Weitzman

This study uses long-read RNA sequencing to identify novel adenovirus transcripts and splice variants not detectable by short-read methods.

bioRxiv · Dec 13, 2019 · PreprintMicrobiology

Whole genome sequencing of Herpes Simplex Virus 1 directly from human cerebrospinal fluid reveals selective constraints in neurotropic viruses.

F. Lassalle, M. A. Beale, T. Bharucha, C. A. Williams, R. J. Williams, J. Cudini, R. A. Goldstein, T. Haque, D. P. Depledge, J. Breuer

This study uses whole genome sequencing of HSV-1 from CSF and skin lesions to identify selective constraints and recombination patterns in neurotropic viruses.

bioRxiv · Dec 6, 2019Evolutionary Biology

Native RNA sequencing on nanopore arrays redefines the transcriptional complexity of a viral pathogen

D. P. Depledge, S. Kalanghad Puthankalam, T. Sadaoka, D. Beady, Y. Mori, D. Placantonakis, I. Mohr, A. Wilson

This study uses nRNA-seq to analyze the herpes simplex virus type 1 transcriptome, identifying a novel intergenic mRNA encoding a fusion protein of ICP0 and L.

bioRxiv · Jul 20, 2018Microbiology