P. Shukla

Glioblastoma induces the recruitment and differentiation of hybrid neutrophils from skull bone marrow

This study identifies hybrid neutrophils with dendritic features in glioblastoma that suppress tumor growth and originate from skull bone marrow.

Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterations

This study identifies the transsulfuration pathway as a targetable metabolic driver of glioblastoma invasion through multi-omic analyses of engineered biomaterials and patient biopsies.

Microparticle-delivered Cxcl9 prolongs Braf inhibitor efficacy in melanoma

The paper shows that delivering Cxcl9 via microparticles enhances the effectiveness of BRAF inhibitors in melanoma by reducing minimal residual disease relapse.

Unification of the M/ORF3-related proteins points to a diversified role for ion conductance in pathogenesis of coronaviruses and other nidoviruses

This study unifies M/ORF3-related proteins across coronaviruses and other nidoviruses, revealing their conserved role in ion conductance and virion assembly, while showing differential evolutionary pressures between M and ORF3 proteins.

Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice

This study shows that Lactobacillus rhamnosus reduces bone loss and improves bone health in Ovx mice by modulating Treg and Th17 cell balance and cytokine profiles.

Human stem cell derived sensory neurons are positioned to support varicella zoster virus latency

This study investigates VZV latency and reactivation in human sensory neurons, finding they resist lytic infection but support latency and reactivation, mirroring in vivo conditions.

Redox-Dependent Condensation Of the Mycobacterial Nucleoid By WhiB4

This paper identifies WhiB4 as a redox-dependent nucleoid condensing protein in Mtb that links oxidative stress response with genome organization and gene expression.

Efficacy of the β-lactam\β-lactamase inhibitor combination is linked to WhiB4 mediated changes in redox physiology of Mycobacterium tuberculosis

This paper shows that the effectiveness of the β-lactam/β-lactamase inhibitor combination against Mtb depends on WhiB4-regulated redox changes, with higher mycothiol redox potential enhancing drug efficacy.