Author

T. Smyth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:ecology & biodiversity· 1

Frequent Co-Authors

A. Payton· 1 shared A. Shah· 1 shared B. Temperton· 1 shared C. Latimer· 1 shared C. McCann· 1 shared D. B. Longley· 1 shared E. Hickman· 1 shared E. M. Kerr· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperImmunology

A. Payton

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Leveraging a Comprehensive Unbiased RNAseq Database Uncovers New Human Monocyte-Derived Macrophage Subtypes Within Commonly Employed In Vitro Polarization Methods

T. Smyth, A. Payton, E. Hickman, J. E. Rager, I. Jaspers

The paper uses an RNA-seq database to show that common in vitro macrophage polarization methods produce distinct, previously undescribed subtypes.

bioRxiv · Apr 4, 2024 · PreprintImmunology

Influence of short and long term processes on SAR11 communities in open ocean and coastal systems

L. M. Bolanos, K. Tait, P. J. Somerfield, R. J. Parsons, S. Giovannoni, T. Smyth, B. Temperton

This study examines SAR11 bacterial ecotype seasonality in two North Atlantic regions, showing that short-term environmental changes can disrupt seasonal patterns.

bioRxiv · Jun 17, 2022Microbiology

Clinical positioning of the IAP antagonist tolinapant (ASTX660) in colorectal cancer

D. B. Longley, N. T. Crawford, K. J. Stott, T. Sessler, C. McCann, W. McDaid, C. Latimer, J. Fox, J. M. Munck, T. Smyth, A. Shah, V. Martins, M. Lawler, P. D. Dunne, E. M. Kerr, , V. M. Coyle

This study shows tolinapant, an IAP inhibitor, enhances chemotherapy-induced apoptosis in colorectal cancer by modulating FLIP and HDACs, suggesting its clinical use in poor prognosis MSS CRC with elevated cIAP1/2.

bioRxiv · Nov 20, 2020Cancer Biology