Author

D. B. Longley

Queen's University Belfast

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 8 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 9 Approach:experimental assay· 5 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:differential expression· 3 Assay:imaging· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

M. Salvucci· 4 shared J. H. M. Prehn· 3 shared M. Lawler· 3 shared N. T. Crawford· 3 shared P. D. Dunne· 3 shared C. Holohan· 2 shared C. McCann· 2 shared E. Bozkurt· 2 shared

Activity by Year

2017-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersCancer Biology

M. Salvucci

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Mitochondrial metabolism is a key determinant of chemotherapy sensitivity in Colorectal Cancer

Deborah Y. Moss, Connor N. Brown, Andrew M. Shaw, Chris McCann, Nikita Lewis, Matilda Downs, Rebecca Wurelly, Ciara Cunningham, Aaron Philips, Niamh Doherty, Sarah Gallagher, William J. McDaid, Andrew J. Roe, Aisling Y. Coughlan, Brenton Cavanagh, , Emma M. Kerr

This study identifies mitochondrial metabolism as a key factor in 5-fluorouracil resistance in colorectal cancer and shows that targeting mitochondrial Complex I can enhance chemotherapy effectiveness.

Nature Metabolism · Jul 23, 2026Peer-reviewedCancer Biology

Spatial Effects of Infiltrating T cells on Neighbouring Cancer Cells and Prognosis in Stage III CRC patients

M. Azimi, S. Cho, E. Bozkurt, E. McDonough, B. Kisakol, A. Matveeva, M. Salvucci, H. Dussmann, C. Firat, N. Urganci, J. Shia, S. McDade, D. B. Longley, F. Ginty, J. H. M. Prehn

The paper investigates the spatial relationship between T cells and cancer cells in stage III CRC patients, finding that closer proximity of T cells to cancer cells is associated with better disease-free survival.

bioRxiv · Jan 30, 2024Cancer Biology

The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect TRAIL-mediated apoptosis

J. Holloway, R. C. Turkington, D. B. Longley, E. Evergren

This study shows that Itch regulates TRAIL-mediated apoptosis by controlling TRAIL-R2 localization and mitochondrial cholesterol trafficking in oesophageal cancer cells.

bioRxiv · May 10, 2023Cell Biology

Patients with mesenchymal tumours and high Fusobacteriales prevalence have worse prognosis in colorectal cancer (CRC)

M. Salvucci, N. T. Crawford, K. Stott, S. Bullman, D. B. Longley, J. H. Prehn

bioRxiv · May 17, 2021Cancer Biology

Stratification Of Chemotherapy-Treated Stage III Colorectal Cancer Patients Using Multiplexed Imaging And Single Cell Analysis Of T Cell Populations

X. Stachtea, M. B. Loughrey, M. Salvucci, A. Lindner, S. Cho, E. McDonough, A. Sood, J. Graf, A. Santamaria-Pang, A. Corwin, P. Laurent-Puig, S. Dasgupta, S. Van Schaeybroeck, M. Lawler, J. H. M. Prehn, , D. B. Longley

This study uses multiplexed imaging and single-cell analysis to classify immune cells in stage III colorectal cancer patients, finding that multi-marker Treg classification better predicts survival than single markers.

bioRxiv · Feb 24, 2021Cancer Biology

Clinical positioning of the IAP antagonist tolinapant (ASTX660) in colorectal cancer

D. B. Longley, N. T. Crawford, K. J. Stott, T. Sessler, C. McCann, W. McDaid, C. Latimer, J. Fox, J. M. Munck, T. Smyth, A. Shah, V. Martins, M. Lawler, P. D. Dunne, E. M. Kerr, , V. M. Coyle

This study shows tolinapant, an IAP inhibitor, enhances chemotherapy-induced apoptosis in colorectal cancer by modulating FLIP and HDACs, suggesting its clinical use in poor prognosis MSS CRC with elevated cIAP1/2.

bioRxiv · Nov 20, 2020Cancer Biology

TRAIL signalling promotes entosis in colorectal cancer

E. Bozkurt, H. Dussmann, M. Salvucci, B. Cavanagh, S. Van Schaeybroeck, D. B. Longley, S. J. Martin, J. H. M. Prehn

This study identifies TRAIL as a promoter of entosis in colorectal cancer cells and links CICs to poor patient prognosis.

bioRxiv · Sep 29, 2020Cancer Biology

FLIP(L) determines p53 induced life or death

A. Lees, A. J. McIntyre, F. Falcone, N. T. Crawford, C. McCann, G. P. Quinn, J. Z. Roberts, T. Sessler, P. F. Gallagher, K. McAllister, K. McLaughlin, W. L. Allen, C. Holohan, L. J. Egan, A. E. Ryan, , S. S. McDade

This study identifies FLIP(L) as a p53 target that determines cell fate by promoting cell cycle arrest and inhibiting apoptosis.

bioRxiv · Nov 28, 2019 · PreprintCancer Biology

Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer

P. D. Dunne, H. G. Coleman, P. Bankhead, M. Alderdice, R. T. Gray, S. McQuaid, V. Bingham, M. B. Loughrey, J. A. James, A. M. McCorry, A. Gilmore, C. Holohan, D. Klingbiel, S. Tejpar, P. G. Johnston, , M. Lawler

The paper identifies Bcl-xL as a prognostic biomarker and predictor of response to adjuvant chemotherapy in BRAF-mutant stage II/III colon cancer using gene expression and immunohistochemistry validation.

bioRxiv · Oct 23, 2017Cancer Biology