Author

N. T. Crawford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. B. Longley· 3 shared C. McCann· 2 shared E. M. Kerr· 2 shared P. D. Dunne· 2 shared S. S. McDade· 2 shared T. Sessler· 2 shared V. M. Coyle· 2 shared A. E. Ryan· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

D. B. Longley

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3 papers

Recent·Most cited

Patients with mesenchymal tumours and high Fusobacteriales prevalence have worse prognosis in colorectal cancer (CRC)

M. Salvucci, N. T. Crawford, K. Stott, S. Bullman, D. B. Longley, J. H. Prehn

bioRxiv · May 17, 2021Cancer Biology

Clinical positioning of the IAP antagonist tolinapant (ASTX660) in colorectal cancer

D. B. Longley, N. T. Crawford, K. J. Stott, T. Sessler, C. McCann, W. McDaid, C. Latimer, J. Fox, J. M. Munck, T. Smyth, A. Shah, V. Martins, M. Lawler, P. D. Dunne, E. M. Kerr, , V. M. Coyle

This study shows tolinapant, an IAP inhibitor, enhances chemotherapy-induced apoptosis in colorectal cancer by modulating FLIP and HDACs, suggesting its clinical use in poor prognosis MSS CRC with elevated cIAP1/2.

bioRxiv · Nov 20, 2020Cancer Biology

FLIP(L) determines p53 induced life or death

A. Lees, A. J. McIntyre, F. Falcone, N. T. Crawford, C. McCann, G. P. Quinn, J. Z. Roberts, T. Sessler, P. F. Gallagher, K. McAllister, K. McLaughlin, W. L. Allen, C. Holohan, L. J. Egan, A. E. Ryan, , S. S. McDade

This study identifies FLIP(L) as a p53 target that determines cell fate by promoting cell cycle arrest and inhibiting apoptosis.

bioRxiv · Nov 28, 2019 · PreprintCancer Biology