CD19-targeting CAR T cells potently redirected to kill solid tumor cells
C. Ambrose, L. Su, L. Wu, F. J. Dufort, T. Stanford, A. Birt, B. J. Hackel, A. A. Hombach, H. Abken, R. R. Lobb, P. D. Rennert
This paper develops CD19-targeting CAR T cells that secrete bridging proteins to enhance tumor targeting and cytotoxicity in solid tumors.
bioRxiv · Mar 25, 2020Cancer Biology