Author

B. J. Hackel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Assay:protein structure· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Harthorn· 2 shared A. W. Golinski· 2 shared R. R. Lobb· 2 shared A. A. Hombach· 1 shared A. Birt· 1 shared A. K. Lewis· 1 shared C. Ambrose· 1 shared D. T. Tresnak· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioengineering

A. Harthorn

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Systematic evaluation of protein-small molecule hybrids on the yeast surface

M. Huang, M. Rueda-Garcia, A. Harthorn, B. J. Hackel, J. A. Van Deventer

This study evaluates protein-small molecule hybrids on yeast surfaces, showing tolerance to chemical diversity and unexpected functional outcomes.

bioRxiv · May 12, 2023Bioengineering

A platform for deep sequence-activity mapping and engineering antimicrobial peptides

M. P. DeJong, S. C. Ritter, K. A. Fransen, D. T. Tresnak, A. W. Golinski, B. J. Hackel

The paper develops a platform to map antimicrobial peptide activity and identifies potent mutants through high-throughput sequencing.

bioRxiv · May 13, 2021Bioengineering

Engineered protein-small molecule conjugates empower selective enzyme inhibition

A. K. Lewis, A. Harthorn, S. M. Johnson, R. R. Lobb, B. J. Hackel

The paper introduces a platform to create protein-small molecule hybrids (PriSMs) that enhance enzyme inhibition specificity and potency compared to small molecules or proteins alone.

bioRxiv · May 5, 2021Bioengineering

High-Throughput Developability Assays Enable Library-Scale Identification of Producible Protein Scaffold Variants

A. W. Golinski, K. M. Mischler, S. Laxminarayan, N. Neurock, M. Fossing, H. Pichman, S. Martiniani, B. J. Hackel

This study develops high-throughput assays to predict protein developability, enabling large-scale identification of producible variants with improved expression, solubility, and stability.

bioRxiv · Dec 14, 2020Bioengineering

CD19-targeting CAR T cells potently redirected to kill solid tumor cells

C. Ambrose, L. Su, L. Wu, F. J. Dufort, T. Stanford, A. Birt, B. J. Hackel, A. A. Hombach, H. Abken, R. R. Lobb, P. D. Rennert

This paper develops CD19-targeting CAR T cells that secrete bridging proteins to enhance tumor targeting and cytotoxicity in solid tumors.

bioRxiv · Mar 25, 2020Cancer Biology