T. Thum

The long non-coding RNA NEAT1 regulates the transcriptional landscape of cardiomyocytes

This study identifies NEAT1 as a calcium-regulated lncRNA that promotes cardiac hypertrophy by modulating GRK2 expression and transcriptional regulation in cardiomyocytes.

SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation

This study shows SGLT2 inhibitors reduce endothelial to mesenchymal transition and cardiac fibroblast activation through effects on mitochondrial respiration, actin cytoskeleton, and specific transporters.

Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA

This study shows that Msi2 induces cardiac hypertrophy and heart failure by causing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.

Long-term ecosystem nitrogen limitation from foliar δ15N data and a land surface model

The paper uses a land surface model and foliar nitrogen isotope data to assess global nitrogen limitation, finding that leaf δ15N trends cannot alone determine nitrogen limitation and that model integration reveals underlying drivers.

Whole-plant optimality predicts changes in leaf nitrogen under variable CO2 and nutrient availability

The paper develops an optimality model to predict leaf nitrogen changes under variable CO2 and nutrient conditions, showing it better captures observed patterns than existing models.