R. Nair

A Drug-Free Pathogen Capture and Neutralizing Nasal Spray to Prevent Emerging Respiratory Infections

This paper introduces a drug-free nasal spray that captures and neutralizes respiratory pathogens, showing high efficacy in mice against influenza.

Androgen blockade primes NLRP3 in macrophages to induce tumor phagocytosis

This study shows that androgen blockade increases NLRP3 in macrophages, which when combined with NLRP3 agonist, enhances cancer cell phagocytosis and tumor control in a mouse model of prostate cancer.

Combined, yet Separate: cocktails of carriers (not drugs) for α-particle therapy of solid tumors expressing moderate-to-low levels of targetable markers

This study demonstrates that using two separate carriers for alpha-particle therapy improves tumor growth inhibition and survival in cancers with low target marker expression, without increasing radioactivity.

HIGH FREQUENCY ROOT DYNAMICS: SAMPLING AND INTERPRETATION USING REPLICATED ROBOTIC MINIRHIZOTRONS

This paper presents an automated system for high-frequency root dynamics monitoring using robotic minirhizotrons and neural networks, showing robust daily time-series under various conditions.

Long-term ecosystem nitrogen limitation from foliar δ15N data and a land surface model

The paper uses a land surface model and foliar nitrogen isotope data to assess global nitrogen limitation, finding that leaf δ15N trends cannot alone determine nitrogen limitation and that model integration reveals underlying drivers.

Potential consequences of the red blood cell storage lesion on cardiac electrophysiology

This study shows that older red blood cell units affect cardiac electrophysiology, likely due to biochemical changes, including hyperkalemia, and highlights risks for certain patient groups.

Id proteins promote a cancer stem cell phenotype in triple negative breast cancer via negative regulation of Robo1

This study shows that Id proteins promote a cancer stem cell phenotype in triple negative breast cancer by negatively regulating Robo1, leading to Myc activation.

Targeting the Id1-Kif11-Aurka axis in triple negative breast cancer using combination therapy

This paper investigates how Id1 and Id3 maintain chemoresistant CSCs in TNBC by targeting Kif11 and Aurka, and explores combination therapy to enhance tumor debulking.

Clinically-relevant cell type cross-talk identified from a human lung tumor microenvironment interactome

The paper identifies clinically relevant cell type interactions in the lung tumor microenvironment using RNA-seq data from sorted cell populations.

Understanding patterns of abiotic and biotic stress resilience to unleash the potential of crop wild relatives for climate-smart legume breeding

This paper identifies patterns of abiotic and biotic stress resilience in Vigna species to guide conservation and breeding for climate-smart legumes.

Selectivity among anti-σ factors by Mycobacterium tuberculosis ClpX influences intracellular levels of Extracytoplasmic Function σ factors

This study shows that mutations in the degron of anti-σ factors in M. tuberculosis affect ClpX-mediated proteolysis, thereby regulating the release of ECF σ factors and gene expression.

Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer

This study identifies Hedgehog signaling to cancer-associated fibroblasts as a driver of cancer stem cell plasticity and chemoresistance in TNBC, showing that targeting this pathway with smoothened inhibitors improves survival in preclinical models and clinical trials.

Identification Of A Native Novel Oncolytic Immunoglobulin On Exfoliated Colon Epithelial Cells: A Bispecific Heterodimeric Chimera Of IgA/IgG

The paper identifies a novel oncolytic immunoglobulin on exfoliated colon epithelial cells that exhibits cytotoxicity against tumor cells and is associated with gastrointestinal progenitor stem cells.