Author

T. V. Silvas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. A. Schiffer· 2 shared H. Matsuo· 2 shared N. Kurt Yilmaz· 2 shared S. Hou· 2 shared B. A. Kelch· 1 shared C. M. Boyd· 1 shared E. A. Nalivaika· 1 shared F. Leidner· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

C. A. Schiffer

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3 papers

Recent·Most cited

A phage satellite tunes inducing phage gene expression using a domesticated endonuclease to balance inhibition and virion hijacking

Z. Netter, C. M. Boyd, T. V. Silvas, K. Seed

This study reveals how the phage satellite PLE in Vibrio cholerae uses a domesticated endonuclease to regulate ICP1 gene expression, balancing inhibition and virion hijacking.

bioRxiv · Nov 28, 2020Microbiology

Structural analysis of the active site and DNA binding of human cytidine deaminase APOBEC3B

S. Hou, T. V. Silvas, F. Leidner, E. A. Nalivaika, H. Matsuo, N. Kurt Yilmaz, C. A. Schiffer

This study identifies the structural basis for APOBEC3B's lower catalytic activity and DNA binding through molecular modeling and mutational analysis.

bioRxiv · Apr 18, 2018Biochemistry

Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions

T. V. Silvas, S. Hou, W. Myint, M. Somasundaran, B. A. Kelch, H. Matsuo, N. Kurt Yilmaz, C. A. Schiffer

This study identifies the APOBEC3A ssDNA binding motif and shows that substrate affinity is influenced by DNA structure, not just sequence, leading to a new model for its sequence preference.

bioRxiv · Aug 17, 2017Biochemistry