H. Matsuo

Genome-wide association study of copy number variations in Parkinson's disease

This study conducts a genome-wide association study of copy number variations in Parkinson's disease, identifying a significant PRKN deletion but limited replication in an independent dataset.

Identification of novel sex determination loci in Japanese weedy melon

This study identifies two novel sex determination loci in Japanese weedy melon, showing unique sex expression due to interactions with known genes.

Discovery of E6AP AZUL binding to UBQLN1/2 in cells, phase-separated droplets, and an AlphaFold-NMR integrated structure

The paper identifies E6AP AZUL binding to UBQLN1/2 UBA domains, shows phase separation, and presents an integrated AlphaFold-NMR structure.

Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state

The paper determines the structure of APOBEC3G bound to a DNA inhibitor, revealing the transition state geometry and providing insights for inhibitor design.

Novel QTLs for cucumber resistance to two Colletotrichum orbiculare strains of different pathogenic races

The paper identifies novel QTLs in cucumber conferring resistance to two different pathogenic races of Colletotrichum orbiculare using genetic mapping of F2:3 families.

A unique small molecule pair controls the plant circadian clock

The paper identifies two small molecules that oppositely regulate the Arabidopsis circadian clock by altering period length, revealing their mode of action through genetic mutants.

Generation of strong casein kinase 1 inhibitor of Arabidopsis thaliana

This study develops a potent CK1 inhibitor, AMI-331, for plant research by optimizing a lead compound through structure-activity relationship studies.

Structural analysis of the active site and DNA binding of human cytidine deaminase APOBEC3B

This study identifies the structural basis for APOBEC3B's lower catalytic activity and DNA binding through molecular modeling and mutational analysis.

Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions

This study identifies the APOBEC3A ssDNA binding motif and shows that substrate affinity is influenced by DNA structure, not just sequence, leading to a new model for its sequence preference.