Author

M. Somasundaran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

C. A. Schiffer· 2 shared J. P. Wang· 2 shared R. W. Finberg· 2 shared A. Cousineau· 1 shared B. A. Kelch· 1 shared C. Xu· 1 shared C.-W. Chang· 1 shared D. Bolon· 1 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersMicrobiology

C. A. Schiffer

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell culture model system utilizing engineered A549 cells to express high levels of ACE2 and TMPRSS2 for investigating SARS-CoV-2 infection and antivirals

C.-W. Chang, K. M. Parsi, M. Somasundaran, E. Vanderleeden, J. Cruz, A. Cousineau, P. Liu, Q. Li, Y. Wang, R. Maehr, J. P. Wang, R. W. Finberg

This paper develops an engineered A549 cell model overexpressing ACE2 and TMPRSS2 to study SARS-CoV-2 infection and antiviral responses.

bioRxiv · Dec 31, 2021Cell Biology

Quantitative Structural Analysis of Influenza Virus by Cryo-electron Tomography and Convolutional Neural Networks

Q. Y. Huang, K. Song, C. Xu, D. Bolon, J. P. Wang, R. W. Finberg, C. A. Schiffer, M. Somasundaran

This paper develops a cryoET processing pipeline using CNNs to characterize the morphology and structure of influenza viruses, improving analysis throughput and enabling subtomogram averaging of glycoproteins.

bioRxiv · Dec 9, 2021Microbiology

Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions

T. V. Silvas, S. Hou, W. Myint, M. Somasundaran, B. A. Kelch, H. Matsuo, N. Kurt Yilmaz, C. A. Schiffer

This study identifies the APOBEC3A ssDNA binding motif and shows that substrate affinity is influenced by DNA structure, not just sequence, leading to a new model for its sequence preference.

bioRxiv · Aug 17, 2017Biochemistry