Author

T. Velkov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Li· 2 shared M. A. K. Azad· 2 shared Y. Zhu· 2 shared B. P. Howden· 1 shared C. B. Landersdorfer· 1 shared D. T. McCarthy· 1 shared G. Rao· 1 shared H. H. Yu· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

J. Li

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Providing insight into the mechanism of action of Cationic Lipidated Oligomers (CLOs) using metabolomics

M. Hussein, M. B. Mahboob, J. R. Tait, J. L. Grace, V. Montembault, L. Fontaine, J. F. Quinn, T. Velkov, M. R. Whittaker, C. B. Landersdorfer

This study uses metabolomics to reveal that C12-o-(BG-D)-10 disrupts bacterial membrane organization and multiple metabolic pathways, contributing to its antimicrobial activity against MRSA.

bioRxiv · Feb 19, 2024Microbiology

Transcriptomic interplay between Acinetobacter baumannii, human macrophage and polymyxin

Z. Y. Kho, M. A. K. Azad, Y. Zhu, M.-L. Han, Q. Zhou, T. Velkov, T. Naderer, J. Li

This study uses dual RNA-sequencing to analyze transcriptomic changes in Acinetobacter baumannii and human macrophages under polymyxin B treatment, revealing key stress response mechanisms and potential therapeutic targets.

bioRxiv · Jan 23, 2024 · PreprintMicrobiology

Diversified repertoire of phage resistance in Klebsiella pneumoniae and bidirectional steering effects impacting antibiotic susceptibility

S. C. Nang, J. Lu, H. H. Yu, H. Wickremasinghe, M. A. K. Azad, M. Han, J. Zhao, G. Rao, P. J. Bergen, T. Velkov, N. Sherry, D. T. McCarthy, S. Aslam, R. T. Schooley, B. P. Howden, , J. Li

The paper investigates phage resistance mechanisms in Klebsiella pneumoniae and shows how these can both increase and decrease antibiotic susceptibility.

bioRxiv · Nov 14, 2022 · PreprintMicrobiology