Author

R. T. Schooley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

S. Aslam· 2 shared A. E. Clark· 1 shared A. F. Carlin· 1 shared A. F. Garretson· 1 shared B. P. Howden· 1 shared C. Rakov· 1 shared D. Gelman· 1 shared D. T. McCarthy· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

S. Aslam

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Author profile →

3 papers

Recent·Most cited

Diversified repertoire of phage resistance in Klebsiella pneumoniae and bidirectional steering effects impacting antibiotic susceptibility

S. C. Nang, J. Lu, H. H. Yu, H. Wickremasinghe, M. A. K. Azad, M. Han, J. Zhao, G. Rao, P. J. Bergen, T. Velkov, N. Sherry, D. T. McCarthy, S. Aslam, R. T. Schooley, B. P. Howden, , J. Li

The paper investigates phage resistance mechanisms in Klebsiella pneumoniae and shows how these can both increase and decrease antibiotic susceptibility.

bioRxiv · Nov 14, 2022 · PreprintMicrobiology

Rethinking Remdesivir: Synthesis, Antiviral Activity and Pharmacokinetics of Oral Lipid Prodrugs

R. T. Schooley, A. F. Carlin, J. R. Beadle, N. Valiaeva, X.-Q. Zhang, A. E. Clark, R. E. McMillian, S. L. Leibel, R. N. McVicar, J. Xie, A. F. Garretson, V. I. Smith, J. A. Murphy, K. Y. Hostetler

This paper develops orally bioavailable lipid prodrugs of Remdesivir that show submicromolar anti-SARS-CoV-2 activity and therapeutic plasma levels in Syrian hamsters.

Antimicrobial Agents and Chemotherapy · Sep 17, 2021Peer-reviewedMicrobiology

Clinical Phage Microbiology:A suggested framework and recommendations for the in-vitro matching steps ‎of phage therapy

D. Gelman, O. Yerushalmy, S. Ben-Porat, C. Rakov, S. Alkalay-Oren, K. Adler, L. Khalifa, M. Abdalrhman, S. Coppenhagen-Glazer, S. Aslam, R. T. Schooley, R. Nir-Paz, R. Hazan

This paper proposes a framework for in vitro phage-antibiotic matching in clinical settings to support personalized phage therapy.

bioRxiv · Feb 23, 2021Microbiology