Author

H. H. Yu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Moradian· 1 shared B. P. Howden· 1 shared D. T. McCarthy· 1 shared D. W. Taylor· 1 shared G. Rao· 1 shared H. Wickremasinghe· 1 shared J. J. Barr· 1 shared J. Li· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperBiochemistry

A. Moradian

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Diversified repertoire of phage resistance in Klebsiella pneumoniae and bidirectional steering effects impacting antibiotic susceptibility

S. C. Nang, J. Lu, H. H. Yu, H. Wickremasinghe, M. A. K. Azad, M. Han, J. Zhao, G. Rao, P. J. Bergen, T. Velkov, N. Sherry, D. T. McCarthy, S. Aslam, R. T. Schooley, B. P. Howden, , J. Li

The paper investigates phage resistance mechanisms in Klebsiella pneumoniae and shows how these can both increase and decrease antibiotic susceptibility.

bioRxiv · Nov 14, 2022 · PreprintMicrobiology

Single subunit degradation of WIZ, a lenalidomide- and pomalidomide dependent substrate of E3 ubiquitin ligase CRL4CRBN

H. H. Yu, J. M. Reitsma, M. J. Sweredoski, A. Moradian, S. Hess, R. J. Deshaies

This study identifies WIZ as a novel substrate of the CRL4CRBN E3 ubiquitin ligase complex that is degraded by lenalidomide and pomalidomide, highlighting the mechanism of IMiD-induced protein degradation.

bioRxiv · Apr 2, 2019 · PreprintBiochemistry

DNA unwinding is the primary determinant of CRISPR-Cas9 activity

S. Gong, H. H. Yu, K. A. Johnson, D. W. Taylor

The paper investigates CRISPR-Cas9 activity, finding that DNA unwinding is the primary determinant of its cleavage efficiency.

bioRxiv · Oct 19, 2017Biochemistry