Mechanism of activation and regulation of Deubiquitinase activity in MINDY1 and MINDY2
S. A. Abdul Rehman, L. A. Armstrong, S. M. Lange, Y. A. Kristariyanto, T. W. Grawert, A. Knebel, D. Svergun, Y. Kulathu
This paper reveals the mechanism of MINDY1 and MINDY2 deubiquitinase activity, showing how substrate interaction relieves autoinhibition and enables cleavage of K48-linked ubiquitin chains.
bioRxiv · Jan 27, 2021Biochemistry