Author

L. A. Armstrong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Y. Kulathu· 3 shared A. Knebel· 2 shared S. M. Lange· 2 shared B. Canal· 1 shared C. Johnson· 1 shared C. T. Lim· 1 shared D. Kwasna· 1 shared D. Svergun· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

Y. Kulathu

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Comprehensive approach to study branched ubiquitinchains reveals roles for K48-K63 branches inVCP/p97-related processes

S. M. Lange, M. R. McFarland, F. Lamoliatte, D. Kwasna, L. Shen, I. Wallace, I. Cole, L. A. Armstrong, A. Knebel, C. Johnson, V. De Cesare, Y. Kulathu

This paper develops a pipeline to study branched ubiquitin chains, identifies debranching enzymes, and reveals their roles in VCP/p97 processes and DNA damage responses.

bioRxiv · Jan 10, 2023Biochemistry

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp3 Papain-like Protease

L. A. Armstrong, R. Beale, G. Bineva-Todd, B. Canal, J. F. Diffley, L. S. Drury, M. Howell, Y. Kulathu, K. Labib, C. T. Lim, J. Milligan, N. O'Reilly, E. Ozono, K. W. Tan, R. Ulferts, , J. Zeng

This study identifies two small molecule inhibitors of SARS-CoV-2 Nsp3 PLpro that inhibit viral replication in cell culture.

bioRxiv · Apr 7, 2021Biochemistry

Mechanism of activation and regulation of Deubiquitinase activity in MINDY1 and MINDY2

S. A. Abdul Rehman, L. A. Armstrong, S. M. Lange, Y. A. Kristariyanto, T. W. Grawert, A. Knebel, D. Svergun, Y. Kulathu

This paper reveals the mechanism of MINDY1 and MINDY2 deubiquitinase activity, showing how substrate interaction relieves autoinhibition and enables cleavage of K48-linked ubiquitin chains.

bioRxiv · Jan 27, 2021Biochemistry