Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain.
F. Pantouli, T. W. Grim, C. L. Schmid, A. Acevedo-Canabal, N. M. Kennedy, T. D. Bannister, L. M. Bohn
This study compares the tolerance and efficacy of morphine, oxycodone, and the biased MOR agonist SR-17018 in mouse pain models, finding SR-17018 retains efficacy in most models despite developing tolerance in some.
bioRxiv · Oct 16, 2020Pharmacology & Toxicology