T. D. Bannister

Hyperactivity in mice induced by opioid agonists with partial intrinsic efficacy and biased agonism; alone and in combination with morphine

The paper shows that noncompetitive MOR agonists reduce morphine-induced hyperactivity while enhancing pain relief, and that receptor-level intrinsic efficacy does not directly correlate with locomotor activity.

Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain.

This study compares the tolerance and efficacy of morphine, oxycodone, and the biased MOR agonist SR-17018 in mouse pain models, finding SR-17018 retains efficacy in most models despite developing tolerance in some.