CYpHER: Catalytic extracellular targeted protein degradation with high potency and durable effect
Z. R. Crook, G. P. Sevilla, P. Young, E. J. Girard, T.-D. Phi, M. Howard, J. Price, J. M. Olson, N. W. Nairn
CYpHER is a targeted protein degradation technology that uses pH-dependent release and the transferrin receptor to deliver drugs to endolysosomes, demonstrating potency and durability in vitro and in vivo.
Nature Communications · Oct 9, 2024Peer-reviewedBioengineering