P. Young

CYpHER: Catalytic extracellular targeted protein degradation with high potency and durable effect

CYpHER is a targeted protein degradation technology that uses pH-dependent release and the transferrin receptor to deliver drugs to endolysosomes, demonstrating potency and durability in vitro and in vivo.

Structural basis for CFTR inhibition by CFTRinh-172

This paper determines the structure of CFTR bound to CFTRinh-172 using cryo-EM, revealing its dual role as a pore blocker and gating modulator.

Alternative cell entry mechanisms for SARS-CoV-2 and multiple animal viruses

This study identifies alternative cell entry mechanisms for SARS-CoV-2 and other viruses, showing some rely on dynamin while others use actin-dependent pathways.

The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 Gamma variant

This study compares glycosylation and antigenicity of SARS-CoV-2 Wu-1 and Gamma variants, finding that an NTD mutation alters glycan site occupancy but not antibody binding.

Geographic patterns of koala retrovirus genetic diversity, endogenization and subtype distributions

The paper analyzes KoRV genetic diversity and endogenization patterns across koala populations, revealing geographic differences in subtype distribution and endogenous sequences.

Inhibition of the ubiquitin-proteasome system by a bioactivatable compound

The paper identifies CBK77, a bioactivatable compound that inhibits the ubiquitin-proteasome system by targeting NQO1, leading to cell death in cancer cells.

Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology

This paper describes a high-throughput method to phenotype KCNH2 variants using automated patch-clamp electrophysiology and Flp-In HEK293 cells, enabling rapid assessment of variant function.

Single-cell transcriptomic profile reveals macrophage heterogeneity in medulloblastoma and their treatment-dependent recruitment

The paper uses single-cell and bulk RNA sequencing to study macrophage heterogeneity in medulloblastoma and shows differential recruitment with targeted vs. radiation therapy.

Deep sequencing of circulating exosomal microRNA allows non-invasive glioblastoma diagnosis

This study identifies a seven-miRNA signature from serum exosomal microRNA that accurately diagnoses glioblastoma with perfect accuracy in validation cohorts.