Author

T.-W. Mu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Organism:human· 1

Frequent Co-Authors

Y.-J. Wang· 3 shared A. E. Schaffer· 1 shared A. Whittsette· 1 shared B. J. Henderson· 1 shared D.-Y. Han· 1 shared F. J. Moss· 1 shared H. Seibert· 1 shared L. Y. Ahn· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

Y.-J. Wang

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Author profile →

3 papers

Recent·Most cited

Pharmacological chaperones restore proteostasis of epilepsy-associated GABAA receptor variants

Y.-J. Wang, H. Seibert, L. Y. Ahn, A. E. Schaffer, T.-W. Mu

This study identifies pharmacological chaperones that restore function to epilepsy-associated GABAA receptor variants by enhancing folding and reducing degradation.

bioRxiv · Apr 18, 2023 · PreprintCell Biology

Hsp47 Promotes Biogenesis of Multi-subunit Neuroreceptors in the Endoplasmic Reticulum

Y.-J. Wang, X.-J. Di, D.-Y. Han, R. Nashmi, B. J. Henderson, F. J. Moss, T.-W. Mu

This study shows Hsp47 enhances GABAA receptor surface expression by binding folded receptors and promoting their assembly and trafficking, with similar effects on other Cys-loop receptors.

bioRxiv · Oct 24, 2022Cell Biology

The Endoplasmic Reticulum Membrane Complex Promotes Proteostasis of GABAA Receptors

A. Whittsette, Y.-J. Wang, T.-W. Mu

This study shows that EMC3 and EMC6 subunits of the endoplasmic reticulum membrane complex interact with GABAA receptors and enhance their trafficking and function, suggesting potential therapeutic applications for neurological diseases.

bioRxiv · Mar 3, 2022Cell Biology