Single-cell-based evidence for GLS1 inhibitor as a bona fide senolytic agent in vivo
Yuki T. Okamura, Teh-Wei Wang, Satoshi Kawakami, Taiki Morimura, Yoshikazu Johmura, Makoto Nakanishi
This study uses single-cell RNA sequencing to show that the GLS1 inhibitor BPTES eliminates inflammatory senescent cells in aged mice and reduces chronic inflammation.
bioRxiv · Jul 22, 2025 · PreprintCell Biology