Phosphodiesterase 3 inhibitors boost bone outgrowth
Takaaki Kawabe, Atsuhiko Ichimura, Tomoki Yasue, Jianhong Li, Haruki Ishikawa, Ga Eun Kim, Hiroki Nagatomo, Naoto Minamino, Yohei Ueda, Hiromu Ito, Miyuki Nishi, Hiroshi Takeshima
This study shows that PDE3 inhibitors enhance bone growth by increasing Ca2+ influx through TRPM7 channels in chondrocytes, suggesting potential repositioning for short stature syndromes.
British Journal of Pharmacology · Jun 2, 2025Peer-reviewedPharmacology & Toxicology