Early detection of pancreatic ductal adenocarcinoma by single-molecule profiling of pancreatic enzyme activities
Shingo X. Sakamoto, Hideto Hiraide, Junpei Hatakeyama, Takashi Kobayashi, Kazuki Takahashi, Takashi Inagaki, Shizuka Takagi‐Niidome, Mayano Minoda, Tatsuya Kawaguchi, Toru Shibayama, Nozomi Iwakura, Masami Kawana, Tadahaya Mizuno, Mitsuyasu Kawaguchi, H Nakagawa, , Yu Kagami
This study develops a blood-based liquid biopsy platform using single-molecule enzyme activity profiling to detect pancreatic ductal adenocarcinoma with high specificity and moderate sensitivity across multiple stages.
bioRxiv · Jun 9, 2026 · PreprintBiochemistry