Yu Kagami

This paper introduces a biosensor-based method for single-molecule enzyme activity profiling without enzyme-specific substrates, enabling absolute quantification of active enzyme molecules in cellular and circulating samples.

This study develops a blood-based liquid biopsy platform using single-molecule enzyme activity profiling to detect pancreatic ductal adenocarcinoma with high specificity and moderate sensitivity across multiple stages.

This study develops fluorogenic ProTide probes to profile carboxypeptidase activities, showing elevated levels in pancreatic cancer patients.

This paper introduces a programmable chemical strategy called SCCR for automated synthesis of protease-activatable molecules, demonstrating its application in generating fluorogenic probes and ADC linkers.

This paper introduces a liquid biopsy platform that detects early-stage pancreatic adenocarcinoma by analyzing single-molecule protease/peptidase activity in blood samples.