Author

Shingo X. Sakamoto

The University of TokyoORCID 0000-0002-2880-5500Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Mayano Minoda· 3 shared Tadahaya MizunoiD· 3 shared Toru KomatsuiD· 3 shared Yasuteru UranoiD· 3 shared Yu KagamiiD· 3 shared Hideto HiraideiD· 2 shared Kazufumi HondaiD· 2 shared N NaganoiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersBiochemistry

Mayano Minoda

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Early detection of pancreatic ductal adenocarcinoma by single-molecule profiling of pancreatic enzyme activities

Shingo X. Sakamoto, Hideto Hiraide, Junpei Hatakeyama, Takashi Kobayashi, Kazuki Takahashi, Takashi Inagaki, Shizuka Takagi‐Niidome, Mayano Minoda, Tatsuya Kawaguchi, Toru Shibayama, Nozomi Iwakura, Masami Kawana, Tadahaya Mizuno, Mitsuyasu Kawaguchi, H Nakagawa, , Yu Kagami

This study develops a blood-based liquid biopsy platform using single-molecule enzyme activity profiling to detect pancreatic ductal adenocarcinoma with high specificity and moderate sensitivity across multiple stages.

bioRxiv · Jun 9, 2026 · PreprintBiochemistry

Synthesis based on covalent capture and release (SCCR): a programmable strategy for automated preparation of protease-activatable molecules

Mayano Minoda, Tadahaya Mizuno, Takumi Iwasaka, Hiroyuki Kusuhara, Yu Kagami, Shingo X. Sakamoto, N Nagano, CHIAKI HORI, Kazufumi Honda, Yasuteru Urano, Toru Komatsu

This paper introduces a programmable chemical strategy called SCCR for automated synthesis of protease-activatable molecules, demonstrating its application in generating fluorogenic probes and ADC linkers.

bioRxiv · Feb 8, 2026 · PreprintBiochemistry

Platform of single-molecule enzyme activity-based liquid biopsy for detection of pancreatic adenocarcinoma at early stages

Shingo X. Sakamoto, Hideto Hiraide, Tadahaya Mizuno, Mayano Minoda, N Nagano, Misa Suzuki, Nozomi Iwakura, Ayumu Kashiro, Satoshi Nara, Chigusa Morizane, Susumu Hijioka, Kazufumi Honda, Yu Kagami, Rikiya Watanabe, Yasuteru Urano, Toru Komatsu

This paper introduces a liquid biopsy platform that detects early-stage pancreatic adenocarcinoma by analyzing single-molecule protease/peptidase activity in blood samples.

bioRxiv · Aug 7, 2025 · PreprintBiochemistry