Author

Hideto Hiraide

Cosomil, Inc. (Japan)ORCID 0000-0002-5476-3746Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Mayano Minoda· 3 shared Toru KomatsuiD· 3 shared Yasuteru UranoiD· 3 shared Yu KagamiiD· 3 shared Kazufumi HondaiD· 2 shared Nozomi Iwakura· 2 shared Shingo X. SakamotoiD· 2 shared Tadahaya MizunoiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersBiochemistry

Mayano Minoda

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Early detection of pancreatic ductal adenocarcinoma by single-molecule profiling of pancreatic enzyme activities

Shingo X. Sakamoto, Hideto Hiraide, Junpei Hatakeyama, Takashi Kobayashi, Kazuki Takahashi, Takashi Inagaki, Shizuka Takagi‐Niidome, Mayano Minoda, Tatsuya Kawaguchi, Toru Shibayama, Nozomi Iwakura, Masami Kawana, Tadahaya Mizuno, Mitsuyasu Kawaguchi, H Nakagawa, , Yu Kagami

This study develops a blood-based liquid biopsy platform using single-molecule enzyme activity profiling to detect pancreatic ductal adenocarcinoma with high specificity and moderate sensitivity across multiple stages.

bioRxiv · Jun 9, 2026 · PreprintBiochemistry

Solid-Phase Synthesis of ProTide Fluorogenic Probes Enables Systematic Profiling of Carboxypeptidase Activity

Toru Komatsu, Mayano Minoda, Takako Uchida, Momoka Hata, Shunsuke Kanai, Hideto Hiraide, Yu Kagami, Kazufumi Honda, Yasuteru Urano

This study develops fluorogenic ProTide probes to profile carboxypeptidase activities, showing elevated levels in pancreatic cancer patients.

Journal of the American Chemical Society · May 19, 2026Peer-reviewedBiochemistry

Platform of single-molecule enzyme activity-based liquid biopsy for detection of pancreatic adenocarcinoma at early stages

Shingo X. Sakamoto, Hideto Hiraide, Tadahaya Mizuno, Mayano Minoda, N Nagano, Misa Suzuki, Nozomi Iwakura, Ayumu Kashiro, Satoshi Nara, Chigusa Morizane, Susumu Hijioka, Kazufumi Honda, Yu Kagami, Rikiya Watanabe, Yasuteru Urano, Toru Komatsu

This paper introduces a liquid biopsy platform that detects early-stage pancreatic adenocarcinoma by analyzing single-molecule protease/peptidase activity in blood samples.

bioRxiv · Aug 7, 2025 · PreprintBiochemistry