Kyohhei Fujita

This paper develops three topical fluorescence probes for intraoperative detection of peritoneal dissemination in high-grade serous ovarian carcinoma, showing high sensitivity and specificity in clinical and mouse models.

This study develops a blood-based liquid biopsy platform using single-molecule enzyme activity profiling to detect pancreatic ductal adenocarcinoma with high specificity and moderate sensitivity across multiple stages.

This study develops water-soluble fluorogenic probes for single-molecule glycosidase activity profiling in blood, revealing -mannosidase as a potential biomarker for liver injury.

This paper develops enzyme activity-based prodrugs for precision oncology, showing reduced toxicity and improved efficacy in tumor models.

The paper develops a bioorthogonal fluorescence probe and engineered enzyme for low-background cancer imaging in mouse models.