Mitochondrial-targeted therapy with elamipretide preserves cardiac function and prevents late mortality in murine sepsis-induced cardiac dysfunction.
Jennie Vu, Cory S. Wagg, Claudia D. Holody, Anson Wong, Takdeer Baidwan, Maryam Lo, Ibrahim Khodabocus, Si Ning Liu, Kimberly F. Macala, Antoine Dufour, John R. Ussher, Hélène Lemieux, Gary D. Lopaschuk, Stephane L. Bourque
This study shows that elamipretide improves cardiac function and prevents mortality in sepsis-induced cardiac dysfunction in mice by restoring mitochondrial function.
bioRxiv · Jul 9, 2026 · PreprintPhysiology