John R. Ussher

This study identifies ZNF281 as a driver of metastatic prostate cancer and shows that targeting it with a novel inhibitor suppresses tumor growth and metastasis in multiple models.

This study shows that elamipretide improves cardiac function and prevents mortality in sepsis-induced cardiac dysfunction in mice by restoring mitochondrial function.

This study identifies a hibernation-inducing factor from snails, SNAP, which induces quiescence and cardioprotection in mice hearts through metabolic rewiring and autophagy during ischemia-reperfusion injury.