Stephane L. Bourque

Maternal iron deficiency elicits divergent cardiac mitochondrial responses in normotensive and hypertensive pregnancy

This study examines how maternal iron deficiency affects cardiac mitochondrial function in hypertensive and normotensive pregnancies, finding altered mitochondrial structure and respiration with no apoptosis.

Mitochondrial-targeted therapy with elamipretide preserves cardiac function and prevents late mortality in murine sepsis-induced cardiac dysfunction.

This study shows that elamipretide improves cardiac function and prevents mortality in sepsis-induced cardiac dysfunction in mice by restoring mitochondrial function.

Real-Time Assessment of Murine Cardiac Oxygenation Using Photoacoustic Imaging

This paper uses photoacoustic imaging to monitor real-time myocardial and vascular oxygenation in mice, showing earlier detection of hypoxia-induced desaturation compared to traditional methods.

A neonatal rat sepsis score captures the time course and severity of disease in a clinically relevant rat peritonitis model.

This paper develops a neonatal rat sepsis model and scoring system to monitor disease severity and time course in a clinically relevant polymicrobial sepsis context.

Early sex-specific organ transcriptional divergence without physiological differences in a murine model of fecal-induced peritonitis

This study examines early septic responses in male and female mice, finding sex-specific transcriptional differences in organs without physiological differences.