Author

Takuya Otsuki

Kyoto University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biochemistry· 1

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Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

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Haruhiko KamadaiD· 1 shared Hiroaki OhnoiD· 1 shared Hiroki AkibaiD· 1 shared Junso FujitaiD· 1 shared Keiichi NambaiD· 1 shared Ryo KanadaiD· 1 shared Shigeyuki MatsumotoiD· 1 shared Tomoko MiyataiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperBiochemistry

Haruhiko KamadaORCID

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1 paper

Recent·Most cited

Conversion of an agonistic anti-TNFR2 biparatopic antibody into an antagonist by insertion of peptide linkers into the hinge region

Takuya Otsuki, Shigeyuki Matsumoto, Junso Fujita, Tomoko Miyata, Keiichi Namba, Ryo Kanada, Yasushi Okuno, Haruhiko Kamada, Hiroaki Ohno, Hiroki Akiba

The paper converts an agonistic anti-TNFR2 biparatopic antibody into an antagonist by inserting peptide linkers into the hinge region, altering its immunocomplex formation.

Journal of Biological Chemistry · Jul 31, 2025Peer-reviewedBiochemistry