X-ray structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation
Wataru Shihoya, Tamaki Izume, Asuka Inoue, Keitaro Yamashita, Francois Marie Ngako Kadji, Kunio Hirata, Junken Aoki, Tomohiro Nishizawa, Osamu Nureki
The paper reports X-ray structures of the human ETB receptor bound to agonists, revealing molecular mechanisms of activation and partial agonism.
Nature Communications · Nov 5, 2018Peer-reviewedMolecular Biology