Junken Aoki

This study identifies PLCXD2 as a phosphatidylinositol-preferring phospholipase that maintains retinal lipid homeostasis and photoreceptor integrity.

This study identifies maternal progesterone signaling through mPRδ as critical for establishing lifelong oral homeostasis via a hormone-lipid-microbiome axis.

This study identifies PLA2G12A's role in Th17 differentiation through lysophospholipid signaling via extracellular vesicles, showing therapeutic potential for Th17-related diseases.

This study identifies METTL7B as a regulator of lipid metabolism and tumor progression in pancreatic cancer, showing its role in promoting cell proliferation, migration, and metastasis.

This study identifies GPR34 as a regulator of microglial amyloid β fibril uptake, showing that its agonist enhances fibril clearance and that its expression declines with age and AD progression.

This study shows that maternal progesterone and adipose mPRε regulate the embryonic nutritional state by affecting glucose provision and metabolic outcomes in offspring.

This study shows that LPLAT11/MBOAT7 is essential for arachidonic acid incorporation into phosphatidylinositol, maintaining radial glial cell integrity and preventing cortical atrophy in developing neocortex.

This study identifies G protein-biased LPAR1 agonism as a mechanism underlying the antidepressant effects of TCAs like amitriptyline, distinguishing them from SSRIs.

The paper identifies m6A as an endogenous ligand for the A3 adenosine receptor, showing it has higher affinity than unmodified adenosine and plays a role in type I allergy.

The paper presents a cryo-EM structure of the human PAC1 receptor bound to PACAP and an engineered Gs heterotrimer, revealing functional differences in the ECD between PAC1R and GLP1R.

The paper reports X-ray structures of the human ETB receptor bound to agonists, revealing molecular mechanisms of activation and partial agonism.