FUS and TAF15 safeguard the critical functions of the ribonucleoprotein network formed by EWSR1 and newly synthesized RNA
Soumya Sundara Rajan, Imran Khan, Tamara Jones, Tayvia Brownmiller, Vernon Justice Ebegboni, Langston Lim, Andy D. Tran, Michael J. Kruhlak, Natasha J. Caplen
This study shows that EWSR1 forms a ribonucleoprotein network with nascent RNA, and its loss leads to compensatory reorganization of FUS and TAF15, revealing functional redundancy in maintaining nascent RNA homeostasis.
bioRxiv · Mar 26, 2026 · PreprintMolecular Biology