Andy D. Tran

This study shows that deep vein thrombosis primes neutrophils to promote brain metastasis in triple-negative breast cancer by enhancing their recruitment and NET formation.

This study demonstrates that cell penetrating thyclotides enhance the cellular uptake and endosomal escape of bioactive peptides, improving their therapeutic potential.

The paper identifies that DUB inhibitors and RNF168-mediated ubiquitylation drive SLFN11 chromatin recruitment, particularly at promoters, and that this process is suppressed by TAK243.

This study shows that EWSR1 forms a ribonucleoprotein network with nascent RNA, and its loss leads to compensatory reorganization of FUS and TAF15, revealing functional redundancy in maintaining nascent RNA homeostasis.

Imaging of mitochondria and lipid droplets (LDs) across mouse liver lobules shows fasting, not Western diet, expands mitochondria-LD contacts; PLIN5 phosphomutants tune contacts and lipid storage.

The paper quantifies CDK activity in mouse embryos and shows it decreases in trophectoderm cells before implantation, correlating with FGF4 signaling, but does not determine cell fate.

This study shows cancer stem cells (CSCs) have distinct population dynamics and are hyper-responsive to microenvironmental cues, which regulate metastasis and therapy response via the YAP/TAZ/TEAD pathway.

This study shows CD28 co-stimulation accelerates ZAP70 recruitment and activation in TCR microclusters by enhancing Lck dynamics and spatial separation of Lck species.

This study identifies ERF as a key transcription factor that facilitates the exit from naive pluripotency by regulating enhancer activity and DNMT3B expression during the transition to primed pluripotency.

This study identifies CTCF as a barrier to 2C-like reprogramming in ESCs, showing its role in maintaining chromatin structure and that its depletion promotes totipotent-like state conversion.