Single-soma transcriptomics of tangle-bearing neurons in Alzheimer's disease reveals the signatures of tau-associated synaptic dysfunction
Marcos Otero‐García, Sameehan Uday Mahajani, Debia Wakhloo, Weijing Tang, Yue-Qiang Xue, Samuel Morabito, Jie Pan, Jane Oberhauser, Angela E. Madira, Tamara Shakouri, Yongning Deng, Thomas F. Allison, Zihuai He, William E. Lowry, Riki Kawaguchi, , Inma Cobos
The paper identifies gene expression signatures in Alzheimer's disease neurons with tau aggregates, revealing shared and subtype-specific molecular changes related to synaptic function and metabolism.
Neuron · Jul 25, 2022Peer-reviewedNeuroscience