A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated processing of dying neurons by human microglia
Ambra Villani, Jana Sophie Wittmann, Tamara Wyss, Izaskun Mallona, Irene Santisteban Ortiz, Nathalie Tichy, Corinna Maria Biermeier, Monique Pena, Ayush Aditya Pal, Darren Gilmour, Simon T. Schafer, Francesca Peri
The paper develops a xenotransplantation model to study human microglia's processing of dying neurons, identifying a lipid-rich compartment called the gastrosome involved in neurodegeneration.
bioRxiv · Aug 27, 2025Cell Biology