A cardiac microphysiological system for screening lipid nanoparticle/mRNA complexes predicts in vivo efficacy for heart transfection
Gabriel Neiman, Mauro W. Costa, Hesong Han, Sheng Zhao, Tammy Ng, Brian A. Siemons, Tomohiro Nishino, Yu Huang, Shyam Lal Jinagal, Kenneth Kun-yu Wu, Luke M. Judge, Bruce R. Conklin, Deepak Srivastava, Niren Murthy, Kevin E. Healy
The paper develops a cardiac microphysiological system to screen lipid nanoparticle/mRNA complexes and identifies a formulation with improved transfection efficiency and reduced off-target liver uptake.
bioRxiv · Mar 7, 2025 · PreprintBioengineering