Author

Brian A. Siemons

University of California, BerkeleyORCID 0009-0009-6075-9653Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:multiome· 1 Assay:proteomics· 1 Research Focus:trajectory inference· 1 Research Focus:transcription & RNA processing· 1

Frequent Co-Authors

Kevin E. HealyiD· 3 shared Gabriel NeimaniD· 2 shared Adrian Ramirez· 1 shared Aslak TveitoiD· 1 shared Brennan KandalaftiD· 1 shared Bruce R. ConkliniD· 1 shared Deepak SrivastavaiD· 1 shared Henrik Nicolay Topnes FinsbergiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBioengineering

Kevin E. HealyORCID

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3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintMay 13, 2026

Drug Proarrhythmic Evaluation in a High Throughput Cardiac New Approach Methodology

Verena Charwat, Adrian Ramirez, Karoline Horgmo Jæger…·Samuel Wall

This paper develops a high-throughput cardiac NAM using hiPSC-derived cardiomyocytes to evaluate drug proarrhythmic potential, showing accurate detection of arrhythmic risk and insights into ion channel effects.

DOI 10.64898/2026.05.11.722965

humanproteomics

𝕏 PostBluesky

BioengineeringCommunications EngineeringPeer-reviewedNov 20, 2025

Pillar arrays as tunable interfacial barriers for microphysiological systems

Ishan Goswami, Yongdeok Kim, Gabriel Neiman…·Kevin E. Healy

This paper introduces a tunable interfacial barrier for microphysiological systems, demonstrating its use in cardiac tissue engineering and drug testing.

2 citations

experimental assaytrajectory inference

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BioengineeringbioRxivPreprintMar 7, 2025

A cardiac microphysiological system for screening lipid nanoparticle/mRNA complexes predicts in vivo efficacy for heart transfection

Gabriel Neiman, Mauro W. Costa, Hesong Han…·Kevin E. Healy

The paper develops a cardiac microphysiological system to screen lipid nanoparticle/mRNA complexes and identifies a formulation with improved transfection efficiency and reduced off-target liver uptake.

1 citation

humanmultiome

𝕏 PostBluesky