Kevin E. Healy

Drug Proarrhythmic Evaluation in a High Throughput Cardiac New Approach Methodology

This paper develops a high-throughput cardiac NAM using hiPSC-derived cardiomyocytes to evaluate drug proarrhythmic potential, showing accurate detection of arrhythmic risk and insights into ion channel effects.

Pillar arrays as tunable interfacial barriers for microphysiological systems

This paper introduces a tunable interfacial barrier for microphysiological systems, demonstrating its use in cardiac tissue engineering and drug testing.

A cardiac microphysiological system for screening lipid nanoparticle/mRNA complexes predicts in vivo efficacy for heart transfection

The paper develops a cardiac microphysiological system to screen lipid nanoparticle/mRNA complexes and identifies a formulation with improved transfection efficiency and reduced off-target liver uptake.

Viscoelastic HyA Hydrogel Promotes Recovery of Muscle Quality and Vascularization in a Murine Model of Delayed Rotator Cuff Repair

This study shows that a viscoelastic HyA hydrogel with encapsulated hFAPs reduces fibrosis, fatty infiltration, and atrophy while promoting vascularization in a delayed rotator cuff repair model.