Structural and biochemical characterization of LIG1 during mutagenic nick sealing of oxidatively damaged ends at the final step of DNA repair
Kanal Elamparithi Balu, Danah Almohdar, Camden Lerner, Jacob Ratcliffe, Qun Tang, Tanay Parwal, Kar Men Lee, Aishwarya Prakash, Melike Çağlayan
This study characterizes LIG1's structural and biochemical interactions with oxidatively damaged DNA during the final steps of base excision repair.
Nucleic Acids Research · Nov 12, 2025Peer-reviewedBiochemistry