Author
University of Florida
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
Kanal Elamparithi Balu, Danah Almohdar, Camden Lerner…·Melike Çağlayan
This study characterizes LIG1's structural and biochemical interactions with oxidatively damaged DNA during the final steps of base excision repair.
Jacob Ratcliffe, Camden Lerner, Kanal Elamparithi Balu…·Melike Çağlayan
This study examines how the K845N mutation in LIG1 affects nick binding and sealing using biochemical, structural, and single-molecule approaches, revealing reduced ligation efficiency and altered binding dynamics.
Surajit Chatterjee, Kar Men Lee, Kanal Elamparithi Balu, Melike Çağlayan
This study uses single-molecule techniques to compare how LIG1 and LIG3 bind and ligate gap and nick DNA substrates, revealing differences in binding dynamics and efficiency.
Mustafa Kalaycioğlu, Mitchell Gulkis, Kar Men Lee…·Melike Çağlayan
This study characterizes LIG1 active site mutants to show F635 and F872 residues are critical for accurate nick ligation and DNA repair.