Aishwarya Prakash

This study identifies a trinuclear metal center in PPM1B that facilitates phosphate hydrolysis through direct substrate coordination and water protonation, revealing a novel catalytic mechanism.

This study characterizes LIG1's structural and biochemical interactions with oxidatively damaged DNA during the final steps of base excision repair.

The paper evaluates WWE and macrodomain proteins as PAR probes in live cells and shows unique PAR dynamics that can modulate the DNA damage response.

The paper presents a computational method to generate synthetic eukaryotic signal peptides using building blocks, validated by Signal-BLAST showing 88% of generated sequences were identified as signal peptides.