Next-Generation saRNA Platforms: Systematic Screening and Engineering Enhances Superior Protein Expression and Organ-Specific Targeting for RNA Therapeutics
Zhen Feng Sun, Yuxiao Liu, Haoyi Zhang, Ting Ge, Yuting Pan, Yang Liu, Miaomiao Wu, Tao Shan, Guoqiang Zhu, Qi Wu, Kangming Chen
This paper optimizes saRNA platforms for enhanced protein expression and organ-specific targeting, identifying three alphavirus-derived constructs with improved performance in vivo.
bioRxiv · Mar 30, 2025 · PreprintMolecular Biology